DOWNREGULATION OF SURFACE AMPA RECEPTOR EXPRESSION IN THE STRIATUM FOLLOWING PROLONGED SOCIAL ISOLATION, A ROLE OF MGLU5 RECEPTORS

Downregulation of surface AMPA receptor expression in the striatum following prolonged social isolation, a role of mGlu5 receptors

Major depressive disorder is a common and serious mood illness.The molecular mechanisms underlying the pathogenesis and symptomatology of depression are poorly understood at present.Multiple neurotransmitter systems are believed to be implicated in depression.Increasing evidence supports glutamatergic transmission as a critical element in depressio

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Investigation of attentional bias in obsessive compulsive disorder with and without depression in visual search.

Whether Obsessive Compulsive Disorder (OCD) is associated with an increased attentional bias to emotive stimuli remains controversial.Additionally, it is unclear whether comorbid depression modulates abnormal emotional processing in OCD.This study examined attentional bias to OC-relevant scenes using a visual search task.Controls, non-depressed and

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Novel recurrent chromosomal aberrations detected in clonal plasma cells of light chain amyloidosis patients show potential adverse prognostic effect: first results from a genome-wide copy number array analysis

Immunoglobulin light chain (AL) amyloidosis is a rare plasma cell dyscrasia characterized by the deposition of abnormal amyloid fibrils in multiple organs, thus impairing their function.In the largest cohort studied up to now of 118 CD138-purified plasma cell samples from previously untreated immunoglobulin light chain amyloidosis patients, we asse

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